Jeffrey Robert Hoffman was born on January 8, 1993, in Latham, New York. He attended Shaker High School and played college baseball for the East Carolina Pirates. The Toronto Blue Jays selected him in the first round of the 2014 MLB draft. Hoffman made his major league debut on August 20, 2016, with the Colorado Rockies. He pitched for the Cincinnati Reds and Philadelphia Phillies before the Minnesota Twins signed him to a minor league contract on February 27, 2023. The Phillies signed him to a minor league contract on March 31, 2023. Hoffman was an NL All-Star in 2024. The Toronto Blue Jays signed him as a free agent on January 10, 2025. On August 3, 2026, the Blue Jays traded Hoffman to the Minnesota Twins for left-handed pitcher Dasan Hill, second baseman Dameury Pena, right-handed pitcher John Klein, and other considerations.