For three innings Tuesday night at Target Field, Bartolo Colon was a veritable Harry Houdini.

The 44-year-old righty worked in and out of danger, and was staked to a 1-0 lead before allowing three solo home runs over a two-inning span on the way to an 8-1 loss to Danny Salazar and the Cleveland Indians in front of nearly 30,000 fans at Target Field.

The loss sent the Twins to a stunning 0-8 against the Indians at home this season. The Twins are 5-1 against Cleveland at Progressive Field this season, however.

Carlos Santana, Jason Kipnis and Edwin Encarnacion issued the gut punches that sent Colon to the showers after just five spotty innings, with Austin Jackson and Santana again adding long balls later in the game as Cleveland scored all eight of its runs on the night via the home run.

Santana homered from both sides of the plate for the second time this season and fifth time in his career. The second home run was also his 14th at Target Field — tying him with Jose Bautista of the Blue Jays for most as a visiting player at the park since its inception in 2010.

Salazar was absolutely brilliant for the Indians, and has been since returning from the disabled list five starts ago after battling a shoulder injury. Salazar fanned 10 Twins batters and walked none, his second double-digit strikeout game in his last three outings and the third time in a row he’s allowed just one earned run. In his five starts since returning, Salazar has allowed just five earned runs (1.39 ERA).

“He threw the ball well,” manager Paul Molitor said of Salazar after the game. “He had some of our guys looking a bit confused. He had a combination of good velocity and location. He’s always had that good changeup.”

The only damage Salazar really allowed came in the second inning, as Eddie Rosario hit a booming double into the right field corner and scampered home on a two-out single off the bat of Byron Buxton.

That gave the Twins a 1-0 lead. The next Twin to reach base did not come until Max Kepler doubled to the right-center gap in the sixth — when the team trailed by a 3-1 margin.

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